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Yoshiyuki Minegishi Selected Research

Tyrosine Kinase 2 Deficiency

10/2022Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.
9/2015Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
12/2007Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency.
11/2006Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.

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Yoshiyuki Minegishi Research Topics

Disease

10Job Syndrome (Hyper-IgE Syndrome)
10/2023 - 08/2007
8Atopic Dermatitis (Atopic Eczema)
01/2023 - 11/2006
6Inflammation (Inflammations)
03/2013 - 08/2005
4Tyrosine Kinase 2 Deficiency
10/2022 - 11/2006
4Infections
10/2021 - 09/2008
4Abscess
09/2015 - 08/2007
3Pneumonia (Pneumonitis)
12/2011 - 08/2007
3Dermatitis
08/2010 - 08/2007
2Eczema
10/2023 - 02/2009
2Virus Diseases (Viral Diseases)
10/2022 - 09/2015
2Anaphylaxis (Anaphylactic Shock)
11/2010 - 04/2008
1Reinfection
10/2023
1Mycoses (Diseases, Fungus)
01/2023
1Hypergammaglobulinemia (Hyperimmunoglobulinemia)
10/2015
1Candidiasis (Moniliasis)
09/2015
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
09/2015
1Lung Injury
11/2013
1Edema (Dropsy)
12/2011
1Staphylococcal Infections
02/2011
1Skin Diseases (Skin Disease)
08/2010
1Tick-Borne Diseases (Tick-Borne Disease)
08/2010
1Tick Infestations
08/2010
1Parasitic Diseases (Parasitic Disease)
12/2009
1Eosinophilia
02/2009
1Bacterial Infections (Bacterial Infection)
09/2008
1Cysts
08/2007
1Graft vs Host Disease (Graft-Versus-Host Disease)
05/2004
1Type 1 Hyper-IgM Immunodeficiency Syndrome
05/2004

Drug/Important Bio-Agent (IBA)

20Immunoglobulin E (IgE)IBA
10/2023 - 08/2005
4STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2023 - 02/2009
4CytokinesIBA
02/2009 - 11/2006
3Interleukin-23 (Interleukin 23)IBA
10/2022 - 12/2011
3Interleukin-10 (Interleukin 10)IBA
09/2015 - 02/2011
3Interleukin-6 (Interleukin 6)IBA
09/2015 - 12/2007
3Proteins (Proteins, Gene)FDA Link
11/2010 - 12/2009
2Interleukin-12 (IL 12)IBA
10/2022 - 09/2015
2Immunoglobulin G (IgG)IBA
11/2010 - 04/2008
2AntigensIBA
11/2010 - 08/2005
2TYK2 Kinase (Tyrosine Kinase 2)IBA
10/2009 - 02/2009
1Transforming Growth Factor-beta Type I ReceptorIBA
10/2021
1Cytokine Receptors (Cytokine Receptor)IBA
10/2021
1Transforming Growth Factor-beta Type II ReceptorIBA
10/2021
1interleukin-21 (interleukin 21)IBA
10/2015
1Interleukin-4 Receptors (Interleukin 4 Receptor)IBA
03/2013
1mouse mast cell protease 11IBA
12/2011
1Interleukin-17 (Interleukin 17)IBA
12/2011
1AntibodiesIBA
11/2010
1OvalbuminIBA
11/2010
1EpitopesIBA
11/2010
1B-Cell Activating FactorIBA
08/2010
1AcaricidesIBA
08/2010
1Diphtheria ToxinIBA
08/2010
1Histamine (Histamine Dihydrochloride)FDA Link
04/2008
1AllergensIBA
04/2008
1Interferon-alpha (Interferon Alfa)IBA
12/2007
1DNA (Deoxyribonucleic Acid)IBA
08/2007
1Busulfan (Busulfex)FDA Link
05/2004
1Methotrexate (Mexate)FDA LinkGeneric
05/2004
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
05/2004
1Cyclosporine (Ciclosporin)FDA LinkGeneric
05/2004

Therapy/Procedure

1Hematopoietic Stem Cell Transplantation
05/2004